Depression is one of the most common mental illnesses that affects adults worldwide. In the U.S., major depressive disorders affect more than 16.1 million adults, which translates to 6.7 percent of the population 18 years or older each year. It is not a disorder that should be taken lightly, as it can result in fatalities due to suicide.

If you are one of the millions experiencing depression, you may have discussed medication options with your doctor, who may have mentioned two common drugs — mirtazapine and sertraline. You may be doing your due diligence and researching which medicine works better for depression, and which drug is stronger. Let’s take a look at the differences.

Side Effects of Mirtazapine

Mirtazapine is routinely used in the treatment of depression; however, the use of the medication may be limited due to its prominent sedative effects. Some individuals may find the side effects too intense and not useful. The drug is also prescribed for anxiety, hot flashes, insomnia, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). The most common side effects of mirtazapine include:

  • Constipation
  • Severe sedation
  • Drowsiness
  • Increased serum cholesterol
  • Increased or decreased appetite
  • Xerostomia (dry mouth due to decreased saliva)

Mirtazapine falls under a different class of drugs known as tetracyclic antidepressants. If your doctor prescribes you this medication, you must monitor your symptoms and report any undesirable side effects that may occur.

Side Effects of Sertraline

Sertraline is a safe and effective treatment for depression, and it holds a far lesser potential for drowsiness than other antidepressants. It is prescribed for major depressive disorder, panic disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder, postpartum depression, and social anxiety disorder. Sertraline may also be prescribed for purposes not listed in this article.

Other common side effects of sertraline include:

  • Dizziness
  • Drowsiness
  • Diarrhea
  • Fatigue
  • Insomnia
  • Dyspepsia
  • Nausea
  • Tremors
  • Headache
  • Anorexia
  • Paresthesia (abnormal skin sensations, such as tingling, burning, numbness)
  • Diaphoresis (unusual sweating)
  • Delayed ejaculation
  • Ejaculation failure
  • Xerostomia (dry mouth due to decreased saliva)

Sertraline falls under a class of drugs known as selective serotonin reuptake inhibitors (SSRIs) and is considered a safe medication. If you experience adverse side effects as a result of usage, call your doctor immediately.

Is Mirtazapine or Sertraline Stronger?

It’s challenging to determine if mirtazapine is stronger than sertraline or vice versa because of the many variables at play. Are you taking other medications?

A handful of pillsDo you have a history of other mental health disorders?

There is a great deal to consider when making this determination.

For some, mirtazapine may act as a strong sedative, which they may consider stronger, while sertraline has no effect at all.

The latter may be true where someone experiences strong effects from sertraline and none from mirtazapine.

We all possess unique characteristics that make this question tough to answer.

If you are experiencing depression and think you need medication, talk with your doctor to find out what will work best for you.

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