Mirtazapine and trazodone are antidepressant drugs used to treat clinical depression. Mirtazapine can also be used to suppress appetite or treat anxiety, nausea, post-traumatic stress syndrome. Mirtazapine and trazodone are very different antidepressants.

Trazodone is a serotonin modulator, while mirtazapine is a tetracyclic antidepressant. Side effects of both drugs are similar, which include weight changes, drowsiness, nausea, and dizziness. The side effects that differ, however, is that trazodone will cause an increased appetite.

Some side effects that differ from mirtazapine in trazodone include diarrhea, tiredness, headache, blurred vision, muscle aches and pain, stuffy nose, constipation, and a change in sexual ability.

Both drugs interact with alcohol, other medicines that make you tired, narcotic pain medicine, sedatives, muscle relaxers, sleeping pills, antifungal medication, blood things, tramadol, and seizure medication.

Severe Side Effects of Mirtazapine

Although mirtazapine is considered a safe medication to treat depression, it may cause adverse effects. Contact your doctor immediately if you experience severe side effects, such as:

  • Agitation
  • Fever
  • Hallucinations
  • Fast or uneven heart rate
  • Feeling unsteady (loss of balance)
  • Loss of coordination
  • Tremors
  • Stiff muscles
  • Confusion
  • Flu-like symptoms
  • Problems with your memory
  • Overactive reflexes
  • Sweating
  • Feeling that you could pass out at any moment
  • Extreme nausea
  • White patches or sores in your mouth or on your lips
  • Inability to focus
  • Severe headache

Severe Side Effects of Trazodone

Trazodone is another commonly used antidepressant medication that doesn’t usually cause severe side effects. However, as you might expect with any medication, we all possess unique brain chemistry that may react poorly with the new drug. In the event this occurs, you must contact your doctor immediately. If the effects become overwhelming, you must go to your closest emergency room. Look out for these symptoms, which include:

  • Fainting
  • Sleep pattern problems
  • Restlessness
  • Extreme mood swings
  • Easily bruising or bleeding
  • Agitation
  • Fast or pounding heartbeat
  • Hallucinations
  • Elevated heart rate
  • Overactive reflexes
  • Diarrhea
  • Very stiff or rigid muscles
  • Losing coordination
  • High fever
  • Memory problems
  • Inability to concentrate
  • Weakness
  • Loss of appetite
  • Unsteadiness
  • Tremors
  • Seizures
  • Shallow breathing or breathing that stops
  • Heavy feelings in your chest
  • Pain that spreads from your arm to your shoulder

If you feel that something isn’t right, please contact your primary care physician immediately. As mentioned above, if any of these side effects occur seemingly out of nowhere and become debilitating, don’t wait; go to the hospital.

Which Medication is Better: Mirtazapine or Trazodone?

When comparing mirtazapine and trazodone, you can’t say one is better than the other. It’s not about personal preference; it’s about what works for your unique brain chemistry.

While someone can use trazodone and have no positive effects, they can move onto mirtazapine and adequately treat their depression.

The same theory applies to trazodone if only mirtazapine works. Doctors will explore your options and test which medications work best while you are treating the condition.

If you are struggling with depression, you must reach out to a licensed psychologist or psychiatrist that can help you find options.

Take into consideration that medications often come with side effects.

In some cases, you’ll have to see if the positives outweigh the negatives.

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